نیوار

نیوار

The Effect of Synbiotic Supplementation on Total Antioxidant Capacity Levels in Adolescents Exposed to Air Pollution: A Randomized, Single-Blind, Controlled Clinical Trial

نوع مقاله : مقاله پژوهشی

نویسندگان
Motahar Heidari Beni 1
Parinaz Poursafa 2
Golnoosh Shahverdi 3
Maryam Zarean 4
Azimeh Maghzi 5
Maryam Yazdi 6
Roya Kelishadi 7
1 Associate Professor, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Postdoctoral research fellow, Faculty of Medicine and Health Technology,Tampere University, Tampere, Finland
3 Postdoctoral research fellow, Faculty of Medicine and Health Technology,Tampere University, Tampere, Finland.
4 Ph.D Candidate, Department of Biology, York University, Toronto.
5 MSc of Biostatistics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
6 Assistant Professor, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
7 Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
10.30467/nivar.2025.233468
چکیده
Background: Exposure to air pollution might increase malondialdehyde (MDA) levels. Synbiotics by changing intestinal flora can decrease the inflammatory markers. There is lack of evidence about the effect of synbiotic supplementation on oxidative stress in children and adolescent. This study aims to evaluate the effect of synbiotic supplementation on MDA in healthy adolescents who were exposed to air pollution.
Methods This randomized single-blind, controlled trial was conducted among 70 participants aged 10-18 years who were exposed to air pollution. Participants were randomly divided into two groups that received either a synbiotic (n= 38) or omega-3 (n= 32) for 8 weeks. MDA was measured at baseline and after the intervention.
Results: MAD levels decreased significantly at the end of the intervention in comparison with baseline in synbiotic group (148.80±80.72 vs 51.54±82.94, p<0.001). In crude model, no significant changes were demonstrated in MDA levels between groups (P=0.75). However, after adjustment the analysis with confounder significant reduction was observed with synbiotic consumption.
Conclusion: synbiotic supplementation might be associated with reduction of MDA levels that may be increased due to air pollution. Investigation the effects of air pollutants on children and adolescent is very important. Further large-scale studies are required to highlight the importance of synbiotic on adverse effects of air pollution in pediatric age groups.
کلیدواژه‌ها
Synbiotics
Dietary supplements
Air pollution
Malondialdehyde
Oxidative stress
Child

عنوان مقاله English

The Effect of Synbiotic Supplementation on Total Antioxidant Capacity Levels in Adolescents Exposed to Air Pollution: A Randomized, Single-Blind, Controlled Clinical Trial

نویسندگان English

Motahar Heidari Beni 1
Parinaz Poursafa 2
Golnoosh Shahverdi 3
Maryam Zarean 4
Azimeh Maghzi 5
Maryam Yazdi 6
Roya Kelishadi 7
1 Associate Professor, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Postdoctoral research fellow, Faculty of Medicine and Health Technology,Tampere University, Tampere, Finland
3 Postdoctoral research fellow, Faculty of Medicine and Health Technology,Tampere University, Tampere, Finland.
4 Ph.D Candidate, Department of Biology, York University, Toronto.
5 MSc of Biostatistics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
6 Assistant Professor, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
7 Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده English

Background: Exposure to air pollution might increase malondialdehyde (MDA) levels. Synbiotics by changing intestinal flora can decrease the inflammatory markers. There is lack of evidence about the effect of synbiotic supplementation on oxidative stress in children and adolescent. This study aims to evaluate the effect of synbiotic supplementation on MDA in healthy adolescents who were exposed to air pollution.
Methods This randomized single-blind, controlled trial was conducted among 70 participants aged 10-18 years who were exposed to air pollution. Participants were randomly divided into two groups that received either a synbiotic (n= 38) or omega-3 (n= 32) for 8 weeks. MDA was measured at baseline and after the intervention.
Results: MAD levels decreased significantly at the end of the intervention in comparison with baseline in synbiotic group (148.80±80.72 vs 51.54±82.94, p<0.001). In crude model, no significant changes were demonstrated in MDA levels between groups (P=0.75). However, after adjustment the analysis with confounder significant reduction was observed with synbiotic consumption.
Conclusion: synbiotic supplementation might be associated with reduction of MDA levels that may be increased due to air pollution. Investigation the effects of air pollutants on children and adolescent is very important. Further large-scale studies are required to highlight the importance of synbiotic on adverse effects of air pollution in pediatric age groups.

کلیدواژه‌ها English

Synbiotics
Dietary supplements
Air pollution
Malondialdehyde
Oxidative stress
Child
1.    Keulers L, Dehghani A, Knippels L, et al. 2022. “Probiotics, prebiotics, and synbiotics to prevent or combat air pollution consequences: The gut-lung axis.” Environmental Pollution, 302:119066.
2.    He L, Cui X, Li Z, et al. 2020. “Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure.” Environmental Science & Technology, 54(18):11405-13.
3.    Romieu I, Barraza-Villarreal A, Escamilla-Nuñez C, et al. 2008. “Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.” The Journal of Allergy and Clinical Immunology, 121(4):903-9.e6.
4.    Hu W, Wang Y, Wang T, et al. 2021. “Ambient particulate matter compositions and increased oxidative stress: Exposure-response analysis among high-level exposed population.” Environment International, 147:106341.
5.    Mas-Bargues C, Escrivá C, Dromant M, et al. 2021. “Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease.” Archives of Biochemistry and Biophysics, 709:108941.
6.    Heshmati J, Farsi F, Shokri F, et al. 2018. “A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress.” 46:66-84.
7.    Mazidi M, Rezaie P, Ferns GA, et al. 2017. “Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials.” Nutrients, 9(1).
8.    Nguyen TTU, Kim HW, Kim W, et al. 2021. “Effects of Probiotics, Prebiotics, and Synbiotics on Uremic Toxins, Inflammation, and Oxidative Stress in Hemodialysis Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Journal of Clinical Medicine, 10(19).
9.    Samah S, Ramasamy K, Lim SM, et al. 2016. “Probiotics for the management of type 2 diabetes mellitus: A systematic review and meta-analysis.” Diabetes Research and Clinical Practice, 118:172-82.
10. Vaghef-Mehrabany E, Homayouni-Rad A, Alipour B, et al. 2016. “Effects of Probiotic Supplementation on Oxidative Stress Indices in Women with Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial.” Journal of the American College of Nutrition, 35(4):291-9.
11. Li Z, Liu Q, Xu Z, et al. 2020. “Association between short-term exposure to ambient particulate air pollution and biomarkers of oxidative stress: A meta-analysis.” Environmental Research, 191:110105.
12. Brigham EP, Woo H, McCormack M, et al. 2019. “Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children.” American Journal of Respiratory and Critical Care Medicine, 199(12):1478-86.
13. Tong H, Zhang S, Shen W, et al. 2022. “Lung Function and Short-Term Ambient Air Pollution Exposure: Differential Impacts of Omega-3 and Omega-6 Fatty Acids.” Annals of the American Thoracic Society, 19(4):583-93.
14. Chen H, Zhang S, Shen W, et al. 2022. “Omega-3 fatty acids attenuate cardiovascular effects of short-term exposure to ambient air pollution.” Particle and Fibre Toxicology, 19(1):12.
15. Kelishadi R, Ardalan G, Gheiratmand R, et al. 2007. “Association of physical activity and dietary behaviours in relation to the body mass index in a national sample of Iranian children and adolescents: CASPIAN Study.” Bulletin of the World Health Organization, 85(1):19-26.
16. Toto A, Wild P, Graille M, et al. 2022. “Urinary Malondialdehyde (MDA) Concentrations in the General Population-A Systematic Literature Review and Meta-Analysis.” Toxics, 10(4).
17. Sadeghi F, Alavi-Naeini A, Mardanian F, et al. 2020. “Omega-3 and vitamin E co-supplementation can improve antioxidant markers in obese/overweight women with polycystic ovary syndrome.” International Journal for Vitamin and Nutrition Research, 90(5-6):477-83.
18. Heshmati J, Morvaridzadeh M, Maroufizadeh S, et al. 2019. “Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials.” Pharmacological Research, 149:104462.
19. Fazelian S, Moradi F, Agah S, et al. 2021. “Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis.” BMC Nephrology, 22(1):160.
20. Bahmani F, Tajadadi-Ebrahimi M, Kolahdooz F, et al. 2016. “The Consumption of Synbiotic Bread Containing Lactobacillus sporogenes and Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial.” Journal of the American College of Nutrition, 35(6):506-13.
21. Zhao J, Yu L, Zhai Q, et al. 2020. “Effects of probiotic administration on hepatic antioxidative parameters depending on oxidative stress models: A meta-analysis of animal experiments.” Journal of Functional Foods, 71:103936.
22. Amirani E, Milajerdi A, Mirzaei H, et al. 2020. “The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials.” Complementary Therapies in Medicine, 49:102361.
23. Chen Y, Yue R, Zhang B, et al. 2020. “Effects of probiotics on blood glucose, biomarkers of inflammation and oxidative stress in pregnant women with gestational diabetes mellitus: A meta-analysis of randomized controlled trials.” Medicina Clinica, 154(6):199-206.
24. Zamani B, Sheikhi A, Namazi N, et al. 2020. “The Effects of Supplementation with Probiotic on Biomarkers of Oxidative Stress in Adult Subjects: a Systematic Review and Meta-analysis of Randomized Trials.” Probiotics and Antimicrobial Proteins, 12(1):102-11.
25. Hadi A, Ghaedi E, Khalesi S, et al. 2020. “Effects of synbiotic consumption on lipid profile: a systematic review and meta-analysis of randomized controlled clinical trials.” European Journal of Nutrition, 59(7):2857-74.
26. Salami M, Kouchaki E, Asemi Z, et al. 2019. “How probiotic bacteria influence the motor and mental behaviors as well as immunological and oxidative biomarkers in multiple sclerosis? A double blind clinical trial.” Journal of Functional Foods, 52:8-13.
27. Nabhani Z, Clark CC, Goudarzi N, et al. 2022. “The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study.” Journal of Diabetes and Metabolic Syndrome, 14(1):1-9.
28. Pandey KR, Naik SR, Vakil BV. 2015. “Probiotics, prebiotics and synbiotics-a review.” Journal of Functional Foods, 52:7577-87.
29. Chapman CM, Gibson GR, Rowland I. 2011. “Health benefits of probiotics: are mixtures more effective than single strains?” European Journal of Nutrition, 50(1):1-17.
30. Fujimori S, Tatsuguchi A, Gudis K, et al. 2007. “High dose probiotic and prebiotic cotherapy for remission induction of active Crohn’s disease.” Journal of Gastroenterology and Hepatology, 22(8):1199-204.

  • تاریخ دریافت 19 فروردین 1404
  • تاریخ بازنگری 15 اردیبهشت 1404
  • تاریخ پذیرش 22 اردیبهشت 1404
  • تاریخ انتشار 01 مهر 1404